In mammalian cells, phospholipids and cholesterol are assembled into bilayer membranes
forming the plasma membrane, nuclear envelope, mitochondria, endoplasmic reticulum …

DGKs (diacylglycerol kinases) are members of a unique and conserved family of
intracellular lipid kinases that phosphorylate DAG (diacylglycerol), catalysing its conversion …

Diacylglycerol (DAG) kinase (DGK) modulates the balance between the two signaling lipids,
DAG and phosphatidic acid (PA), by phosphorylating DAG to yield PA. To date, ten …

Anergic T cells have altered diacylglycerol metabolism, but whether that altered metabolism
has a causative function in the induction of T cell anergy is not apparent. To test the …

This review focuses on two phospholipase activities involved in eukaryotic signal
transduction. The action of the phosphatidylinositol-specific phospholipase C enzymes …

Diacylglycerol (DAG) is an important lipid that is both an intermediate in lipid biosynthetic
pathways and can act as a signaling lipid. The majority of signaling DAG is generated by …

Many intracellular signaling pathways are initiated by a simple reaction, the hydrolysis of
phosphatidylinositol 4, 5-bisphosphate (PIP2) 1 (1), which results in a transient rise in the …

Diacylglycerol kinases (DGKs) phosphorylate the second-messenger diacylglycerol (DAG)
to phosphatidic acid (PA). The family of DGKs is well conserved among most species. Nine …

An improvement of current methods is needed for simple, rapid, and precise quantification of
cellular lipids, including rare species of biologically active cellular lipids, such as …

Distinct, structurally different forms of sn-1, 2-diacylglycerol are found in cells, these are
polyunsaturated, mono-or di-unsaturated and saturated. The pathways that generate or …