Cellular and molecular mechanisms of the organogenesis and development, and function of the mammalian parathyroid gland

Y Kameda - Cell and Tissue Research, 2023 - Springer
Serum calcium homeostasis is mainly regulated by parathormone (PTH) secreted by the
parathyroid gland. Besides PTH and Gcm2, a master gene for parathyroid differentiation …

Critical role of the BAF chromatin remodeling complex during murine neural crest development

KW Bi-Lin, PV Seshachalam, T Tuoc, A Stoykova… - PLoS …, 2021 - journals.plos.org
The BAF complex plays an important role in the development of a wide range of tissues by
modulating gene expression programs at the chromatin level. However, its role in neural …

Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue

A Venkat, MJ Carlino, BR Lawton, ML Prasad… - Genome …, 2024 - genome.cshlp.org
Studies on human parathyroids are generally limited to hyperfunctioning glands owing to the
difficulty in obtaining normal human tissue. We therefore obtained non-human primate …

Neural crest-specific deletion of Rbfox2 in mice leads to craniofacial abnormalities including cleft palate

DM Cibi, MM Mia, S Guna Shekeran, LS Yun… - Elife, 2019 - elifesciences.org
Alternative splicing (AS) creates proteomic diversity from a limited size genome by
generating numerous transcripts from a single protein-coding gene. Tissue-specific …

Genome sequencing in families with congenital limb malformations

J Elsner, MA Mensah, M Holtgrewe, J Hertzberg… - Human Genetics, 2021 - Springer
The extensive clinical and genetic heterogeneity of congenital limb malformation calls for
comprehensive genome-wide analysis of genetic variation. Genome sequencing (GS) has …

Semaphorin 3D inhibits proliferation and migration of papillary thyroid carcinoma by regulating MAPK/ERK signaling pathway

R Hai, Q You, F Wu, G Qiu, Q Yang, L Shu, L Xie… - Molecular Biology …, 2022 - Springer
Abstract Background Semaphorin 3D (SEMA3D) plays an important role in the occurrence
and development of multifarious cancers. However, the relationship between SEMA3D and …

The induction of parathyroid cell differentiation from human induced pluripotent stem cells promoted via TGF-α/EGFR signaling

R Nakatsuka, T Kato, R Zhang, Y Uemura… - Stem Cells and …, 2023 - liebertpub.com
The parathyroid gland plays an essential role in mineral and bone metabolism. Cultivation of
physiological human parathyroid cells has yet to be established and the method by which …

Sema3d Restrained Hepatocellular Carcinoma Progression Through Inactivating Pi3k/Akt Signaling via Interaction With FLNA

Y Li, C Xu, B Sun, F Zhong, M Cao, L Yang - Frontiers in Oncology, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors worldwide due
to the high incidence rate of metastasis and recurrence. Semaphorin 3d (Sema3d) has been …

Quantifying adaptive divergence of the snowfinches in a common landscape

H She, Z Jiang, G Song, PGP Ericson… - Diversity and …, 2022 - Wiley Online Library
Aim Species living in a shared environment face similar selective pressures and often
evolve adaptive divergence to avoid competition. Quantifying phenotypic divergence and its …

Semaphorin4A promotes lung cancer by activation of NF-κB pathway mediated by PlexinB1

X Wei, Z Liu, Y Shen, H Dong, K Chen, X Shi, Y Chen… - PeerJ, 2023 - peerj.com
Background Lung cancer (LC) is the most prevalent cancer with a poor prognosis.
Semaphorin4A (Sema4A) is important in many physiological and pathological processes …