The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is an enzyme that degrades the essential
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …

There is good evidence that the kynurenine pathway (KP) and one of its products, quinolinic
acid (QUIN), play a role in the pathogenesis of neurological diseases, in particular AIDS …

Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …

The kynurenine pathway is a major route of l-tryptophan catabolism producing neuroactive
metabolites implicated in neurodegeneration and immune tolerance. We characterized the …

Infection with the human immunodeficiency virus type-1 (HIV) results in acute and
progressive numeric loss of CD4+ T-helper cells and functional impairment of T-cell …

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid
tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the …

There is good evidence that the kynurenine pathway (KP) and one of its products, quinolinic
acid (QUIN) play a role in the pathogenesis of neurological diseases. Monocytic cells are …

In just under 20 years the kynurenine family of compounds has developed from a group of
obscure metabolites of the essential amino acid tryptophan into a source of intensive …

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can result in neurological dysfunction with devastating consequences in a significant …