Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for
approximately 90% of primary liver cancers, arises almost exclusively in the setting of …

Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Immune checkpoint blockade (ICB) therapy has attracted widespread attention in cancer
treatment. Due to the low immunogenicity and immune suppression state in the tumor …

Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis
(NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we …

Cysteinyl aspartate specific proteinase (Caspase)‐8 has long been considered a promoter
of apoptosis and part of the mechanism by which cytotoxic drugs kill cancer cells. With the …