MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D Xie, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

A network-biology perspective of microRNA function and dysfunction in cancer

CP Bracken, HS Scott, GJ Goodall - Nature Reviews Genetics, 2016 - nature.com
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

Deep-belief network for predicting potential miRNA-disease associations

X Chen, TH Li, Y Zhao, CC Wang… - Briefings in …, 2021 - academic.oup.com
MicroRNA (miRNA) plays an important role in the occurrence, development, diagnosis and
treatment of diseases. More and more researchers begin to pay attention to the relationship …

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate-and tissue-specific microRNAs

E Londin, P Loher, AG Telonis… - Proceedings of the …, 2015 - National Acad Sciences
Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

WBSMDA: within and between score for MiRNA-disease association prediction

X Chen, CC Yan, X Zhang, ZH You, L Deng, Y Liu… - Scientific reports, 2016 - nature.com
Increasing evidences have indicated that microRNAs (miRNAs) are functionally associated
with the development and progression of various complex human diseases. However, the …

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Semi-supervised learning for potential human microRNA-disease associations inference

X Chen, GY Yan - Scientific reports, 2014 - nature.com
MicroRNAs play critical role in the development and progression of various diseases.
Predicting potential miRNA-disease associations from vast amount of biological data is an …

LRSSLMDA: Laplacian regularized sparse subspace learning for MiRNA-disease association prediction

X Chen, L Huang - PLoS computational biology, 2017 - journals.plos.org
Predicting novel microRNA (miRNA)-disease associations is clinically significant due to
miRNAs' potential roles of diagnostic biomarkers and therapeutic targets for various human …

An analysis of human microRNA and disease associations

M Lu, Q Zhang, M Deng, J Miao, Y Guo, W Gao, Q Cui - PloS one, 2008 - journals.plos.org
It has been reported that increasingly microRNAs are associated with diseases. However,
the patterns among the microRNA-disease associations remain largely unclear. In this study …

RWRMDA: predicting novel human microRNA–disease associations

X Chen, MX Liu, GY Yan - Molecular BioSystems, 2012 - pubs.rsc.org
Recently, more and more research has shown that microRNAs (miRNAs) play critical roles
in the development and progression of various diseases, but it is not easy to predict potential …