Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and
environmental variation. However, even genetically identical cells in identical environments …

INTRODUCTION Microbial populations display heterogeneous gene expression profiles that
result in phenotypic differences between individual bacteria. This diversity can allow …

INTRODUCTION The copy number and intracellular localization of RNA are important
regulators of gene expression. Measurement of these properties at the transcriptome scale …

Understanding how complex phenotypes arise from individual molecules and their
interactions is a primary challenge in biology that computational approaches are poised to …

The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

In individual cells, transcription is a random process obeying single-molecule kinetics. Often,
it occurs in a bursty, intermittent manner. The frequency and size of these bursts affect the …

Gene expression occurs either as an episodic process, characterized by pulsatile bursts, or
as a constitutive process, characterized by a Poisson-like accumulation of gene products. It …

Transcription of highly expressed genes has been shown to occur in stochastic bursts. But
the origin of such ubiquitous phenomenon has not been understood. Here, we present the …

Non-Markovian models of stochastic biochemical kinetics often incorporate explicit time
delays to effectively model large numbers of intermediate biochemical processes. Analysis …