Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the
formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of …