Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy,
infection and transplantation, patient outcomes are linked to the degree of immune …

The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance,
cell death and compromised organ function. This is first observed in the thymus, the primary …

Thymic epithelial cell differentiation, growth and function depend on the expression of the
transcription factor Foxn1; however, its target genes have never been physically identified …

Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune
diseases. This protection may be due, in part, to higher androgen levels in males. Androgen …

Development of the primary T‐cell repertoire takes place in the thymus. The linked
processes of T‐cell differentiation and T‐cell repertoire selection each depend on …

The thymus is the primary lymphoid organ responsible for the generation and maturation of
T cells. Thymic epithelial cells (TECs) account for the majority of thymic stromal components …

Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular
mechanisms that maintain adult TECs are poorly understood. Here, we show that a …