Mitochondrial protein transport: Versatility of translocases and mechanisms
JD Busch, LF Fielden, N Pfanner, N Wiedemann - Molecular Cell, 2023 - cell.com
Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
[HTML][HTML] Mitophagy in the retina: viewing mitochondrial homeostasis through a new lens
JI Jiménez-Loygorri, R Benítez-Fernández… - Progress in Retinal and …, 2023 - Elsevier
Mitochondrial function is key to support metabolism and homeostasis in the retina, an organ
that has one of the highest metabolic rates body-wide and is constantly exposed to …
that has one of the highest metabolic rates body-wide and is constantly exposed to …
A cytosolic surveillance mechanism activates the mitochondrial UPR
The mitochondrial unfolded protein response (UPRmt) is essential to safeguard
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …
mitochondria from proteotoxic damage by activating a dedicated transcriptional response in …
[HTML][HTML] Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin
Parkinson's disease (PD) is the second most common neurodegenerative disease and
represents a looming public health crisis as the global population ages. While the etiology of …
represents a looming public health crisis as the global population ages. While the etiology of …
The ER membrane protein complex restricts mitophagy by controlling BNIP3 turnover
JM Delgado, LW Shepard, SW Lamson, SL Liu… - The EMBO …, 2024 - embopress.org
Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy.
However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are …
However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, are …
The mechanisms and roles of mitochondrial dynamics in C. elegans
D Campbell, S Zuryn - Seminars in Cell & Developmental Biology, 2024 - Elsevier
If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power
grid that regulates how that energy output is directed and maintained in response to unique …
grid that regulates how that energy output is directed and maintained in response to unique …
A TNIP1-driven systemic autoimmune disorder with elevated IgG4
A Medhavy, V Athanasopoulos, K Bassett, Y He… - Nature …, 2024 - nature.com
Whole-exome sequencing of two unrelated kindreds with systemic autoimmune disease
featuring antinuclear antibodies with IgG4 elevation uncovered an identical ultrarare …
featuring antinuclear antibodies with IgG4 elevation uncovered an identical ultrarare …
Mitochondrial quality control pathways sense mitochondrial protein import
LP Lee-Glover, TE Shutt - Trends in Endocrinology & Metabolism, 2024 - cell.com
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional
proteome, which enables mitochondria to perform a myriad of important cellular functions …
proteome, which enables mitochondria to perform a myriad of important cellular functions …
[HTML][HTML] Maintenance of mitochondrial homeostasis for Alzheimer's disease: strategies and challenges
Y Han, D Liu, Y Cheng, Q Ji, M Liu, B Zhang, S Zhou - Redox Biology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its
early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of …
early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of …
Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation
J Ma, L Liu, L Song, J Liu, L Yang, Q Chen, JY Wu… - Cell Death & …, 2023 - nature.com
Though TDP-43 protein can be translocated into mitochondria and causes mitochondrial
damage in TDP-43 proteinopathy, little is known about how TDP-43 is imported into …
damage in TDP-43 proteinopathy, little is known about how TDP-43 is imported into …