Single-cell droplet microfluidics for biomedical applications

D Liu, M Sun, J Zhang, R Hu, W Fu, T Xuanyuan, W Liu - Analyst, 2022 - pubs.rsc.org
Single-cell manipulation and analysis is critical to the study of many fundamental biological
processes and uncovering cellular heterogeneity, and presents the potential for extremely …

Droplet microfluidics for high-throughput analysis of antibiotic susceptibility in bacterial cells and populations

W Postek, P Garstecki - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus Antibiotic-resistant bacteria are an increasing concern both in everyday life and
specialized environments such as healthcare. As the rate of antibiotic-resistant infections …

Single-cell pathogen diagnostics for combating antibiotic resistance

H Li, K Hsieh, PK Wong, KE Mach, JC Liao… - Nature Reviews …, 2023 - nature.com
Bacterial infections and antimicrobial resistance are a major cause for morbidity and
mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where …

Microfluidics for antibiotic susceptibility testing

W Postek, N Pacocha, P Garstecki - Lab on a Chip, 2022 - pubs.rsc.org
The rise of antibiotic resistance is a threat to global health. Rapid and comprehensive
analysis of infectious strains is critical to reducing the global use of antibiotics, as informed …

Combating antimicrobial resistance via single-cell diagnostic technologies powered by droplet microfluidics

K Hsieh, KE Mach, P Zhang, JC Liao… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Antimicrobial resistance is a global threat that if left unchecked could lead to 10
million annual mortalities by 2050. One factor contributing to the rise of multi-drug-resistant …

[HTML][HTML] Advances in AI-assisted biochip technology for biomedicine

DR Solovchuk - Biomedicine & Pharmacotherapy, 2024 - Elsevier
The integration of biochips with AI opened up new possibilities and is expected to
revolutionize smart healthcare tools within the next five years. The combination of …

Bacterial classification and antibiotic susceptibility testing on an integrated microfluidic platform

AA Sklavounos, CR Nemr, SO Kelley, AR Wheeler - Lab on a Chip, 2021 - pubs.rsc.org
With the prevalence of bacterial infections and increasing levels of antibiotic resistance
comes the need for rapid and accurate methods for bacterial classification (BC) and …

Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level

K Zhang, S Qin, S Wu, Y Liang, J Li - Chemical science, 2020 - pubs.rsc.org
Infectious diseases caused by multidrug resistant (MDR) bacterial pathogens are impending
threats to global health. Since delays in identifying drug resistance would significantly …

High-throughput microfluidic droplets in biomolecular analytical system: A review

L Zhang, R Parvin, M Chen, D Hu, Q Fan… - Biosensors and …, 2023 - Elsevier
Droplet microfluidic technology has revolutionized biomolecular analytical research, as it
has the capability to reserve the genotype-to-phenotype linkage and assist for revealing the …

Environmental, mechanistic and evolutionary landscape of antibiotic persistence

C Bollen, E Louwagie, N Verstraeten, J Michiels… - EMBO …, 2023 - embopress.org
Recalcitrant infections pose a serious challenge by prolonging antibiotic therapies and
contributing to the spread of antibiotic resistance, thereby threatening the successful …