Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Sustained drug delivery strategies have many potential benefits for treating a range of
diseases, particularly chronic diseases that require treatment for years. For many chronic …

Topical drug delivery to the posterior segment of the eye is a very complex challenge.
However, topical delivery is highly desired, to achieve an easy-to-use treatment option for …

Pigmented ocular tissues contain melanin within the intracellular melanosomes. Drugs bind
to melanin at varying extent that ranges from no binding to extensive binding. Binding may …

Light-activated liposomes permit site and time-specific drug delivery to ocular and systemic
targets. We combined a light activation technology based on indocyanine green with a …

Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy,
providing both temporal and spatial control of drug release. We have developed light …

Melanin binding of drugs is known to increase drug concentrations and retention in
pigmented eye tissues. Even though the correlation between melanin binding in vitro and …

A large variety of drugs bind effectively to melanin, and this binding influences their ocular
pharmacokinetic and distribution profiles. We aimed to establish a correlation between in …

Melanin pigment has a significant role in ocular pharmacokinetics, because many drugs
bind at high extent to melanin in the retinal pigment epithelial cells. Most retinal pigment …