Nearly all FDA approved drugs and bioactive small molecules exert their effects by binding
to and modulating proteins. Consequently, understanding how small molecules interact with …

DNA–protein interactions regulate critical biological processes. Identifying proteins that bind
to specific, functional genomic loci is essential to understand the underlying regulatory …

Photoaffinity labeling is a powerful technique to interrogate drug‐protein interactions in
native cellular environments. Photo‐cross‐linkers are instrumental for this technique …

More than half of the global novel drugs are directly or indirectly derived from natural
products (NPs) because of their better selectivity towards proteins. Traditional medicines …

Covalent inhibitors with an electrophilic warhead have received considerable attention due
to their remarkable pharmacological properties. However, the electrophilic warhead in …

Many chemotherapeutics, such as paclitaxel, are administered intravenously as they suffer
from poor oral bioavailability, partly because of efflux mechanism of P-glycoprotein in the …

GPI-anchored folate receptor α (FRα) is an attractive anticancer drug target and diagnosis
marker in fundamental biology and medical research due to its significant expression on …

The “inverse drug discovery” strategy is a potent means of exploring the cellular targets of
latent electrophiles not typically used in medicinal chemistry. Cyclopropenone, a powerful …

We report the molecular design of a novel multifunctional reagent and its application for light-
controlled selective protein labeling. This molecule integrates functions of protein–ligand …

Background Radioiodide (131I) is commonly used to treat thyroid cancer and hyperthyroidis.
131I released during nuclear accidents, have resulted in increased incidence of thyroid …