[HTML][HTML] Nanomaterial delivery systems for mRNA vaccines
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …
development of lipid nanoparticle delivery systems that not only efficiently express the …
mRNA vaccine delivery using lipid nanoparticles
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …
Actively targeted nanomedicines for precision cancer therapy: Concept, construction, challenges and clinical translation
The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …
research across different fields including materials science, nanotechnology, biotechnology …
Nanomedicine-based approaches for mRNA delivery
Messenger RNA (mRNA) has immense potential for developing a wide range of therapies,
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
including immunotherapy and protein replacement. As mRNA presents no risk of integration …
Progress in the development of lipopolyplexes as efficient non-viral gene delivery systems
Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery
vectors. Non-viral vectors have become the research interest of many researchers because …
vectors. Non-viral vectors have become the research interest of many researchers because …
Lipid-based mRNA vaccine delivery systems
P Midoux, C Pichon - Expert review of vaccines, 2015 - Taylor & Francis
Synthetic mRNAs can become biopharmaceutics allowing vaccination against cancer,
bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs …
bacterial and virus infections. Clinical trials with direct administration of synthetic mRNAs …
Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor …
We report the preparation of mannosylated nanoparticles loaded with messenger RNA
(mRNA) that enhance the transfection of dendritic cells (DCs) in vivo and the anti-B16F10 …
(mRNA) that enhance the transfection of dendritic cells (DCs) in vivo and the anti-B16F10 …
[HTML][HTML] Atherton–Todd reaction: mechanism, scope and applications
SS Le Corre, M Berchel… - Beilstein journal of …, 2014 - beilstein-journals.org
Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …
Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells
A Le Moignic, V Malard, T Benvegnu… - Journal of Controlled …, 2018 - Elsevier
Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens
demonstrated safety and induction of tumor-specific immune responses. Their proper …
demonstrated safety and induction of tumor-specific immune responses. Their proper …
[HTML][HTML] Peptide-based nanoassemblies in gene therapy and diagnosis: paving the way for clinical application
Nanotechnology approaches play an important role in developing novel and efficient
carriers for biomedical applications. Peptides are particularly appealing to generate such …
carriers for biomedical applications. Peptides are particularly appealing to generate such …