Adhesion protein structure, molecular affinities, and principles of cell-cell recognition
The ability of cells to organize into multicellular structures in precise patterns requires that
they" recognize" one another with high specificity. We discuss recent progress in …
they" recognize" one another with high specificity. We discuss recent progress in …
Protocadherins at the crossroad of signaling pathways
A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
Adhesion-based self-organization in tissue patterning
Since the proposal of the differential adhesion hypothesis, scientists have been fascinated
by how cell adhesion mediates cellular self-organization to form spatial patterns during …
by how cell adhesion mediates cellular self-organization to form spatial patterns during …
Clustered protocadherin cis-interactions are required for combinatorial cell–cell recognition underlying neuronal self-avoidance
G Wiseglass, N Boni, K Smorodinsky-Atias… - Proceedings of the …, 2024 - pnas.org
In the developing human brain, only 53 stochastically expressed clustered protocadherin
(cPcdh) isoforms enable neurites from individual neurons to recognize and self-avoid while …
(cPcdh) isoforms enable neurites from individual neurons to recognize and self-avoid while …
Family-wide structural and biophysical analysis of binding interactions among non-clustered δ-protocadherins
Non-clustered δ1-and δ2-protocadherins, close relatives of clustered protocadherins,
function in cell adhesion and motility and play essential roles in neural patterning. To …
function in cell adhesion and motility and play essential roles in neural patterning. To …
TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex
Cerebral cortex expansion is a hallmark of mammalian brain evolution; yet, how increased
neurogenesis is coordinated with structural and functional development remains largely …
neurogenesis is coordinated with structural and functional development remains largely …
Pcdh19 mediates olfactory sensory neuron coalescence during postnatal stages and regeneration
The mouse olfactory system regenerates constantly throughout life. While genes critical for
the initial projection of olfactory sensory neurons (OSNs) to the olfactory bulb have been …
the initial projection of olfactory sensory neurons (OSNs) to the olfactory bulb have been …
Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics
PCDH19 Clustering Epilepsy (CE) is an intriguing early-onset seizure, autism and
neurocognitive disorder with unique inheritance. The causative gene, PCDH19, is on the X …
neurocognitive disorder with unique inheritance. The causative gene, PCDH19, is on the X …
Following the Evolutionary Paths of Dscam1 Proteins toward Highly Specific Homophilic Interactions
G Wiseglass, R Rubinstein - Molecular Biology and Evolution, 2024 - academic.oup.com
Many adhesion proteins, evolutionarily related through gene duplication, exhibit distinct and
precise interaction preferences and affinities crucial for cell patterning. Yet, the evolutionary …
precise interaction preferences and affinities crucial for cell patterning. Yet, the evolutionary …
Trans-splicing facilitated by RNA pairing greatly expands sDscam isoform diversity but not homophilic binding specificity
S Hou, G Li, B Xu, H Dong, S Zhang, Y Fu, J Shi… - Science …, 2022 - science.org
The Down syndrome cell adhesion molecule 1 (Dscam1) gene can generate tens of
thousands of isoforms via alternative splicing, which is essential for nervous and immune …
thousands of isoforms via alternative splicing, which is essential for nervous and immune …