Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Perturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in
metabolic-dysfunction-associated steatotic liver disease (MASLD), formerly known as …

Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Endoplasmic reticulum (ER)-mitochondria contact sites are crucial to allow Ca 2+ flux
between them and a plethora of proteins participate in tethering both organelles together …

Ferroptosis is a recently proposed cell death mechanism characterized by iron-dependent
lipid peroxidation. Reactive oxygen/nitrogen species (ROS/RNS) are responsible for lipid …

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease
worldwide, ranging from liver steatosis to nonalcoholic steatohepatitis, which ultimately …

Metabolic homeostasis balances the production and consumption of energetic molecules to
maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the …

Mitochondrial network architecture plays a critical role in cellular physiology. Indeed,
alterations in the shape of mitochondria upon exposure to cellular stress can cause the …

The flexibility between the wide array of hepatic functions relies on calcium (Ca 2+)
signalling. Indeed, Ca 2+ is implicated in the control of many intracellular functions as well …

Nonalcoholic steatohepatitis (NASH) is multifactorial that lifestyle, genetic, and
environmental factors contribute to its onset and progression, thereby posing a challenge for …