Highlighting membrane protein structure and function: A celebration of the Protein Data Bank
Biological membranes define the boundaries of cells and compartmentalize the chemical
and physical processes required for life. Many biological processes are carried out by …
and physical processes required for life. Many biological processes are carried out by …
Magic Angle Spinning NMR of Proteins: High-Frequency Dynamic Nuclear Polarization and 1H Detection
Magic angle spinning (MAS) NMR studies of amyloid and membrane proteins and large
macromolecular complexes are an important new approach to structural biology. However …
macromolecular complexes are an important new approach to structural biology. However …
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
Structure and Mechanism of the Influenza A M218–60 Dimer of Dimers
We report a magic angle spinning (MAS) NMR structure of the drug-resistant S31N mutation
of M218–60 from Influenza A. The protein was dispersed in diphytanoyl-sn-glycero-3 …
of M218–60 from Influenza A. The protein was dispersed in diphytanoyl-sn-glycero-3 …
Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus
Anti-influenza drugs, amantadine and rimantadine, targeting the M2 channel from influenza
A virus are no longer effective because of widespread drug resistance. S31N is the …
A virus are no longer effective because of widespread drug resistance. S31N is the …
Recent advances in magic angle spinning solid state NMR of membrane proteins
S Wang, V Ladizhansky - Progress in nuclear magnetic resonance …, 2014 - Elsevier
Membrane proteins mediate many critical functions in cells. Determining their three-
dimensional structures in the native lipid environment has been one of the main objectives …
dimensional structures in the native lipid environment has been one of the main objectives …
Virus structures and dynamics by magic-angle spinning NMR
G Porat-Dahlerbruch, A Goldbourt… - Annual review of …, 2021 - annualreviews.org
Techniques for atomic-resolution structural biology have evolved during the past several
decades. Breakthroughs in instrumentation, sample preparation, and data analysis that …
decades. Breakthroughs in instrumentation, sample preparation, and data analysis that …
Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus …
Influenza virus infections lead to numerous deaths and millions of hospitalizations each
year. One challenge facing anti-influenza drug development is the heterogeneity of the …
year. One challenge facing anti-influenza drug development is the heterogeneity of the …
Solid state NMR strategy for characterizing native membrane protein structures
Unlike water soluble proteins, the structures of helicaltransmembrane proteins depend on a
very complex environment. These proteins sit in the midst of dramatic electrical and …
very complex environment. These proteins sit in the midst of dramatic electrical and …
Dynamic Nuclear Polarization Study of Inhibitor Binding to the M218–60 Proton Transporter from Influenza A
We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding
to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In …
to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In …