Update on the pathogenesis and therapy of atopic dermatitis

H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical Reviews in Allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …

[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies

JMGR de Morales, L Puig, E Daudén, JD Cañete… - Autoimmunity …, 2020 - Elsevier
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …

The IL-4, IL-13 and IL-31 pathways in atopic dermatitis

C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …

[HTML][HTML] Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?

C Gorzelanny, C Mess, SW Schneider, V Huck… - Pharmaceutics, 2020 - mdpi.com
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

The role of tight junctions in skin barrier function and dermal absorption

K Bäsler, S Bergmann, M Heisig, A Naegel… - Journal of Controlled …, 2016 - Elsevier
The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …

Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches

M Moyle, F Cevikbas, JL Harden… - Experimental …, 2019 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is
characterized by persistent itch and marked redness. AD is associated with an increased …

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell …

T Czarnowicki, J Gonzalez, A Shemer… - Journal of Allergy and …, 2015 - Elsevier
Background Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD)
have provided controversial results and were mostly performed before the identification of …

[HTML][HTML] Role of antimicrobial peptides in skin barrier repair in individuals with atopic dermatitis

HLT Nguyen, JV Trujillo-Paez, Y Umehara… - International Journal of …, 2020 - mdpi.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …

[HTML][HTML] Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently

S Bergmann, B von Buenau, S Vidal-y-Sy, M Haftek… - Scientific reports, 2020 - nature.com
The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …

Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis

R Tokumasu, K Yamaga, Y Yamazaki… - Proceedings of the …, 2016 - National Acad Sciences
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently
noted that the characteristics of epidermal barrier functions critically influence the …