Update on the pathogenesis and therapy of atopic dermatitis
H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical Reviews in Allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
eczematous lesions and intense itch. Although it most often starts in infancy and affects …
[HTML][HTML] Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies
Abstract Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of
intensive research because of its crucial role in the pathogenesis of different diseases …
intensive research because of its crucial role in the pathogenesis of different diseases …
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
C Dubin, E Del Duca… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Atopic dermatitis (AD) is the most common inflammatory skin disease. It has a
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …
complex pathophysiology, with a combination of immune dysregulation and intrinsic barrier …
[HTML][HTML] Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them?
Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …
The role of tight junctions in skin barrier function and dermal absorption
K Bäsler, S Bergmann, M Heisig, A Naegel… - Journal of Controlled …, 2016 - Elsevier
The skin protects our body from external assaults like pathogens, xenobiotics or UV
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …
irradiation. In addition, it prevents the loss of water and solutes. To fulfill these important …
Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches
Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is
characterized by persistent itch and marked redness. AD is associated with an increased …
characterized by persistent itch and marked redness. AD is associated with an increased …
Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell …
T Czarnowicki, J Gonzalez, A Shemer… - Journal of Allergy and …, 2015 - Elsevier
Background Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD)
have provided controversial results and were mostly performed before the identification of …
have provided controversial results and were mostly performed before the identification of …
[HTML][HTML] Role of antimicrobial peptides in skin barrier repair in individuals with atopic dermatitis
HLT Nguyen, JV Trujillo-Paez, Y Umehara… - International Journal of …, 2020 - mdpi.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …
complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are …
[HTML][HTML] Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
S Bergmann, B von Buenau, S Vidal-y-Sy, M Haftek… - Scientific reports, 2020 - nature.com
The transmembrane protein claudin-1 is a major component of epidermal tight junctions
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …
(TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 …
Dose-dependent role of claudin-1 in vivo in orchestrating features of atopic dermatitis
R Tokumasu, K Yamaga, Y Yamazaki… - Proceedings of the …, 2016 - National Acad Sciences
Atopic dermatitis (AD) is a chronic inflammatory skin disease in humans. It was recently
noted that the characteristics of epidermal barrier functions critically influence the …
noted that the characteristics of epidermal barrier functions critically influence the …