The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Increasing evidence suggests that metabolites produced by the gut microbiota play a crucial
role in host–microbe interactions. Dietary tryptophan ingested by the host enters the gut …

Numerous health problems including acute critical illness, cancer, diseases associated with
chronic inflammation, and neurological disorders often result in skeletal muscle weakness …

Abstract Angiotensin converting enzyme-2 (ACE2) is a multifunctional transmembrane
protein recently recognised as the entry receptor of the virus causing COVID-19. In the renin …

Skeletal muscle is a tissue that shows the most plasticity in the body; it can change in
response to physiological and pathological stimuli. Among the diseases that affect skeletal …

Over the last decade, it has become clear that the role of angiotensin II extends far beyond
recognized renal and cardiovascular effects. The presence of an autologous renin …

Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

Overactivation of the renin–angiotensin (Ang) system (RAS) increases the classical arm
(Ang-converting enzyme (ACE)/Ang II/Ang type 1 receptor (AT1R)) to the detriment of the …

The renin–angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-
electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating …

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
been considered a public health emergency, extensively investigated by researchers …