Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
The rapid replication of HIV-1 and the errors made during viral replication cause the virus to
evolve rapidly in patients, making the problems of vaccine development and drug therapy …
evolve rapidly in patients, making the problems of vaccine development and drug therapy …
Innate sensing of DNA virus genomes
DNA viruses are linked to many infectious diseases and contribute significantly to human
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …
Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 Å resolution
AL Gnatt, P Cramer, J Fu, DA Bushnell, RD Kornberg - Science, 2001 - science.org
The crystal structure of RNA polymerase II in the act of transcription was determined at 3.3 Å
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …
Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids
We have found that the efficiency of fluorescence resonance energy transfer between Cy3
and Cy5 terminally attached to the 5′ ends of a DNA duplex is significantly affected by the …
and Cy5 terminally attached to the 5′ ends of a DNA duplex is significantly affected by the …
[HTML][HTML] Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA: DNA
We have determined the 3.0 Å resolution structure of wild‐type HIV‐1 reverse transcriptase
in complex with an RNA: DNA oligonucleotide whose sequence includes a purine‐rich …
in complex with an RNA: DNA oligonucleotide whose sequence includes a purine‐rich …
A-form conformational motifs in ligand-bound DNA structures
XJ Lu, Z Shakked, WK Olson - Journal of molecular biology, 2000 - Elsevier
Recognition and biochemical processing of DNA requires that proteins and other ligands
are able to distinguish their DNA binding sites from other parts of the molecule. In addition to …
are able to distinguish their DNA binding sites from other parts of the molecule. In addition to …
Martini coarse-grained force field: extension to RNA
JJ Uusitalo, HI Ingólfsson, SJ Marrink, I Faustino - Biophysical journal, 2017 - cell.com
RNA has an important role not only as the messenger of genetic information but also as a
regulator of gene expression. Given its central role in cell biology, there is significant interest …
regulator of gene expression. Given its central role in cell biology, there is significant interest …
A structural model of transcription elongation
N Korzheva, A Mustaev, M Kozlov, A Malhotra… - Science, 2000 - science.org
The path of the nucleic acids through a transcription elongation complex was tracked by
mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or …
mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or …
2'-O-acetamido modified monomers and oligomers
M Manoharan, AM Kawasaki, PD Cook… - US Patent …, 2000 - Google Patents
Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also
provided is a novel method of deprotection of oligomeric compounds. Oligomeric com …
provided is a novel method of deprotection of oligomeric compounds. Oligomeric com …
Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts
B Rydberg, J Game - … of the National Academy of Sciences, 2002 - National Acad Sciences
Misincorporated ribonucleotides in DNA will cause DNA backbone distortion and may be
targeted by DNA repair enzymes. Using double-stranded oligonucleotide probes containing …
targeted by DNA repair enzymes. Using double-stranded oligonucleotide probes containing …