WEE1 kinase plays a crucial role in the G2–M cell-cycle checkpoint arrest for DNA repair
before mitotic entry. Normal cells repair damaged DNA during G1 arrest; however, cancer …

The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …

Peritoneal metastasis (PM) is the main site of gastric cancer (GC) distant metastasis and
indicates an extremely poor prognosis and survival. Hypoxia is a common feature of …

HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …

Cellular senescence is a complex biological process that leads to irreversible cell‐cycle
arrest. Various extrinsic and intrinsic insults are associated with the onset of cellular …

Previously, it has been shown that pancreatic ductal adenocarcinoma (PDA) tumors exhibit
high levels of hypoxia, characterized by low oxygen pressure (pO 2) and decreased O 2 …

Cancer aggressiveness may result from the selective pressure of a harsh nutrient-deprived
microenvironment. Here we illustrate how such conditions promote chemotherapy …

Pancreatic cancer (pancreatic ductal adenocarcinoma, PDA) is infamously moving to the top
of the list as one of the most lethal cancers with an overall 5 year survival rate of 7%. Multiple …