Accurate control of gene expression in the right cell at the right moment is of fundamental
importance to animal development and homeostasis. At the heart of gene regulation lie the …

In eukaryotes, unlike in bacteria, gene order has typically been assumed to be random.
However, the first statistically rigorous analyses of complete genomes, together with the …

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins
(together termed XFPs) were selectively expressed in neurons. All four XFPs labeled …

Villin, an actin bundling protein found in the apical brush border of absorptive tissues, is one
of the first structural genes to be transcriptionally activated in the embryonic intestinal …

Abstract Bacteriophage P1 Cre/loxP based systems can be used to manipulate the genomes
of mice in vivo and in vitro, allowing the generation of tissue‐specific conditional mutants …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Locus control regions (LCRs) are operationally defined by their ability to enhance the
expression of linked genes to physiological levels in a tissue-specific and copy number …

In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

The efficient introduction of somatic mutations in a given gene, at a given time, in a specific
cell type, will facilitate studies of gene function and the generation of animal models for …

The aorta-gonad-mesonephros region plays an important role in hematopoietic stem cell
(HSC) development during mouse embryogenesis. The vascular endothelial cadherin+ …