[HTML][HTML] Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
HW Ong, X Yang, JL Smith, S Taft-Benz, S Howell… - Molecules, 2024 - mdpi.com
The host kinase casein kinase 2 (CSNK2) has been proposed to be an antiviral target
against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in …
against β-coronaviral infection. To pharmacologically validate CSNK2 as a drug target in …
Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve
SM Min, FM Bashore, JL Smith, TM Havener, S Howell… - 2024 - chemrxiv.org
We optimized our highly potent and cell-active chemical probe for phosphatidylinositol-3-
phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved …
phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved …
Design and Synthesis of Kinase Inhibitors as Anti-Infective Agents for Malaria and COVID-19
HW Ong - 2024 - search.proquest.com
DESIGN AND SYNTHESIS OF KINASE INHIBITORS AS ANTI-INFECTIVE AGENTS FOR
MALARIA AND COVID-19 Han Wee Ong A dissertation submitted Page 1 DESIGN AND …
MALARIA AND COVID-19 Han Wee Ong A dissertation submitted Page 1 DESIGN AND …