Erythropoiesis occurs mostly in bone marrow and ends in blood stream. Mature red blood
cells are generated from multipotent hematopoietic stem cells, through a complex maturation …

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

The pathophysiology of sickle cell disease (SCD) is driven by chronic inflammation fueled by
damage associated molecular patterns (DAMPs). We show that elevated cell-free DNA …

Hemolysis is a pathological feature of several diseases of diverse etiology such as
hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Sickle cell disease (SCD) is an inherited blood disorder characterized by sickled red blood
cells (RBCs), which are more sensitive to haemolysis and can contribute to disease …

β-Thalassemia is a genetic anemia caused by partial or complete loss of β-globin synthesis,
leading to ineffective erythropoiesis and RBCs with a short life span. Currently, there is no …

Patients with sickle cell disease (SCD) suffer from intense pain that can start during infancy
and increase in severity throughout life, leading to hospitalization and poor quality of life. A …