Background Dynamic transmission models are increasingly being used to improve our
understanding of the epidemiology of healthcare-associated infections (HCAI). However …

Purpose: This document seeks to establish guidance for the evaluation and management of
women with recurrent urinary tract infections (rUTI) to prevent inappropriate use of …

Antibiotic-resistant infections complicate treatment and increase morbidity and mortality.
Mathematical modeling has played an integral role in improving our understanding of …

The rapid rise of antibiotic resistance, combined with the increasing cost and difficulties to
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …

The evolution of resistance to antibiotics is a major public health problem and an example of
rapid adaptation under natural selection by antibiotics. The dynamics of antibiotic resistance …

The adaptive landscape analogy has found practical use in recent years, as many have
explored how their understanding can inform therapeutic strategies that subvert the …

Antibiotic resistance represents a growing medical concern where raw, clinical datasets are
under-exploited as a means to track the scale of the problem. We therefore sought patterns …

Background Mathematical transmission models are increasingly used to guide public health
interventions for infectious diseases, particularly in the context of emerging pathogens; …

Can we exploit our burgeoning understanding of molecular evolution to slow the progress of
drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to …

The rise of resistance together with the shortage of new broad-spectrum antibiotics
underlines the urgency of optimizing the use of available drugs to minimize disease burden …