The clinical manifestation of metastasis in a vital organ is the final stage of cancer
progression and the main culprit of cancer-related mortality. Once established, metastasis is …

Acute inflammation is a response to an alteration induced by a pathogen or a physical or
chemical insult, which functions to eliminate the source of the damage and restore …

Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …

Tumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs)
that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating metastatic disease for which
better therapies are urgently needed. Macrophages enhance metastasis in many cancer …

Tumor microenvironment is considered nowadays as one of the main players in cancer
development and progression. Tumor microenvironment is highly complex and consists of …

DNA damaging agents are potent inducers of cell death triggered by apoptosis. Since these
agents induce a plethora of different DNA lesions, it is firstly important to identify the specific …

Portal vein tumor thrombus (PVTT) is strongly correlated to a poor prognosis for patients with
hepatocellular carcinoma (HCC). In this study, we uncovered a causative link between …

Metastasis occurs when genetically unstable cancer cells adapt to a tissue
microenvironment that is distant from the primary tumor. This process involves both the …

Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known
functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and …