Development of fluorescence polarization (FP) assays, especially in a competitive manner,
is a potent and mature tool for measuring the binding affinities of small molecules. This …

Protein interactions underlie most molecular events in biology. Many methods have been
developed to identify protein partners, to measure the affinity with which these biomolecules …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …

Cellular functioning requires the orchestration of thousands of molecular interactions in time
and space. Yet most molecules in a cell move by diffusion, which is sensitive to external …

Glucans are the most abundant class of macromolecule polymers in fungi, which are
commonly found in Ascomycota and Basidiomycota. Fungal glucans are not only essential …

Abstract Purpose of Review This review summarizes the clinical presentation and provides
an update on the current strategies for diagnosis of Pompe disease. We will review the …

Glycogen dysregulation is a hallmark of aging, and aberrant glycogen drives metabolic
reprogramming and pathogenesis in multiple diseases. However, glycogen heterogeneity in …

The polymorphic fungus Candida albicans remains a leading cause of both invasive and
superficial mycoses, including vulvovaginal candidiasis (VVC). Metabolic plasticity …

Glycogen is a biologically essential macromolecule that is directly involved in multiple
human diseases. While its primary role in carbohydrate storage and energy metabolism in …

Adult polyglucosan body disease (APBD) and Lafora disease (LD) are autosomal recessive
glycogen storage neurological disorders. APBD is caused by mutations in the glycogen …