Targeting PI3K/Akt signaling in prostate cancer therapy

M Hashemi, A Taheriazam, P Daneii… - Journal of Cell …, 2023 - Springer
Urological cancers have obtained much attention in recent years due to their mortality and
morbidity. The most common and malignant tumor of urological cancers is prostate cancer …

Cancer-associated fibroblast heterogeneity, activation and function: implications for prostate cancer

JS Owen, A Clayton, HB Pearson - Biomolecules, 2022 - mdpi.com
The continuous remodeling of the tumor microenvironment (TME) during prostate
tumorigenesis is emerging as a critical event that facilitates cancer growth, progression and …

Molecular landscape of c-Myc signaling in prostate cancer: A roadmap to clinical translation

MA Faskhoudi, P Molaei, M Sadrkhanloo… - … -Research and Practice, 2022 - Elsevier
The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc
signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can …

SPS, a sulfated galactoglucan of Laetiporus sulphureus, exhibited anti-inflammatory activities

MK Lu, CI Jen, CH Chao, YC Hsu, LT Ng - International Journal of …, 2023 - Elsevier
Laetiporus sulphureus is an edible and medicinal mushroom. A sulfated galactoglucan
(SPS) was isolated by the papain method. Polysaccharides (PS) were isolated by hot water …

Transcription factor Fli-1 as a new target for antitumor drug development

L Li, J Yu, S Cheng, Z Peng, H Luo - International Journal of Biological …, 2022 - Elsevier
The transcription factor Friend leukemia virus integration 1 (Fli-1) belonging to the E26
Transformation-Specific (ETS) transcription factor family is not only expressed in normal …

[HTML][HTML] The study of a novel CDK8 inhibitor E966-0530–45418 that inhibits prostate cancer metastasis in vitro and in vivo

TY Ho, TY Sung, SL Pan, WJ Huang, KC Hsu… - Biomedicine & …, 2023 - Elsevier
Prostate cancer is a prevalent malignancy among men globally, and androgen deprivation
therapy is the conventional first-line treatment for metastatic prostate cancer. While …

Mechanisms of prostate cancer cells survival and their therapeutic targeting

T Pejčić, Z Todorović, S Đurašević… - International Journal of …, 2023 - mdpi.com
Prostate cancer (PCa) is today the second most common cancer in the world, with almost
400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older …

Transcriptome Profiling of Prostate Cancer, Considering Risk Groups and the TMPRSS2-ERG Molecular Subtype

AA Kobelyatskaya, EA Pudova, IV Katunina… - International Journal of …, 2023 - mdpi.com
Molecular heterogeneity in prostate cancer (PCa) is one of the key reasons underlying the
differing likelihoods of recurrence after surgical treatment in individual patients of the same …

Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

D Kong, C Ye, C Zhang, X Sun, F Wang… - Journal of Experimental …, 2023 - Springer
Background Bone is the most common site of metastasis of prostate cancer (PCa). PCa
invasion leads to a disruption of osteogenic-osteolytic balance and causes abnormal bone …

[HTML][HTML] The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors

MT Palano, M Gallazzi, M Cucchiara… - … of Targeted Anti …, 2022 - ncbi.nlm.nih.gov
Prostate cancer (PCa) accounts as the most common non-cutaneous disease affecting
males, and as the first cancer, for incidence, in male. With the introduction of the concept of …