Background Acute respiratory distress syndrome (ARDS) is a life‐threatening condition
caused by direct or indirect injury to the lungs. Despite improvements in clinical …

Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to
define adequately. Despite its importance as a public health problem, efforts to develop and …

The incidence of sepsis continues to increase. Sepsis and its sequelae are the leading
causes of death in medical and surgical ICUs. 1• 2 According to the Centers for Disease …

Our current understanding of sepsis and multiple organ dysfunction needs to be revised, as
the uniformly negative results of new therapies for these disorders suggest. Previous …

Murray and Nadel's Textbook of Respiratory Medicine has long been the definitive and
comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth …

Objectives: To determine which multicenter randomized controlled trials in critically ill
patients have shown that the study intervention was associated with a statistically significant …

Novel strategies for the treatment of sepsis | Nature Medicine Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To …

Objectives Our primary goal was to evaluate the impact on in-hospital mortality rate of
adequate empirical antibiotic therapy, after controlling for confounding variables, in a cohort …

Background Localized inflammation is a physiological protective response which is
generally tightly controlled by the body at the site of injury. Loss of this local control or an …

Background Mortality from sepsis and septic shock remains high. Results of trials on
intravenous immunoglobulins (IVIG) as adjunctive therapy for sepsis have been conflicting …