Aneuploidy is a hallmark of cancer and a major cause of miscarriages in humans. It is
caused by chromosome segregation errors during cell divisions. Evidence is mounting that …

Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …

Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …

Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein
expression remain poorly understood. To uncover how chromosome copy number changes …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …

Cancer cells display persistent underlying chromosomal instability, with individual tumour
types intriguingly exhibiting characteristic subsets of whole, and subchromosomal …

Microtubule-targeted agents are commonly used for cancer treatment, though many patients
do not benefit. Microtubule-targeted drugs were assumed to elicit anticancer activity via …

How cells control gene expression is a fundamental question. The relative contribution of
protein-level and RNA-level regulation to this process remains unclear. Here, we perform a …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …