[HTML][HTML] The multifaceted roles of Ku70/80
S Zahid, M Seif El Dahan, F Iehl… - International Journal of …, 2021 - mdpi.com
DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …
Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends
M Bétermier, LA Klobutcher, E Orias - Microbiology and Molecular …, 2023 - Am Soc Microbiol
Ciliated protozoa undergo large-scale developmental rearrangement of their somatic
genomes when forming a new transcriptionally active macronucleus during conjugation …
genomes when forming a new transcriptionally active macronucleus during conjugation …
A small RNA-guided PRC2 complex eliminates DNA as an extreme form of transposon silencing
C Wang, T Solberg, XX Maurer-Alcala, EC Swart… - Cell reports, 2022 - cell.com
In animal germlines, transposons are silenced at the transcriptional or post-transcriptional
level to prevent deleterious expression. Ciliates employ a more direct approach by …
level to prevent deleterious expression. Ciliates employ a more direct approach by …
Mechanisms of DNA transposition
AB Hickman, F Dyda - Mobile DNA III, 2015 - Wiley Online Library
In this chapter, we provide an overview of the fundamental concepts of DNA transposition
mechanisms. Our aim is to emphasize basic themes and, in this effort, we will focus on …
mechanisms. Our aim is to emphasize basic themes and, in this effort, we will focus on …
DNA transposition at work
AB Hickman, F Dyda - Chemical reviews, 2016 - ACS Publications
DNA transposons are defined segments of DNA that are able to move from one genomic
location to another. Movement is facilitated by one or more proteins, called the transposase …
location to another. Movement is facilitated by one or more proteins, called the transposase …
Programmed genome rearrangements in ciliates
I Rzeszutek, XX Maurer-Alcalá, M Nowacki - Cellular and Molecular Life …, 2020 - Springer
Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and
germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly …
germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly …
Plugged into the Ku-DNA hub: The NHEJ network
P Frit, V Ropars, M Modesti, JB Charbonnier… - Progress in biophysics …, 2019 - Elsevier
In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken …
Six domesticated PiggyBac transposases together carry out programmed DNA elimination in Paramecium
J Bischerour, S Bhullar, C Denby Wilkes, V Régnier… - Elife, 2018 - elifesciences.org
The domestication of transposable elements has repeatedly occurred during evolution and
domesticated transposases have often been implicated in programmed genome …
domesticated transposases have often been implicated in programmed genome …
Programmed Rearrangement in Ciliates: Paramecium
M Betermier, S Duharcourt - Mobile DNA III, 2015 - Wiley Online Library
Ciliates belong to a monophyletic group of unicellular eukaryotes within the Alveolate
branch (1). The species that have been used as model organisms are free‐living organisms …
branch (1). The species that have been used as model organisms are free‐living organisms …
Improved methods and resources for paramecium genomics: transcription units, gene annotation and gene expression
O Arnaiz, E Van Dijk, M Bétermier, M Lhuillier-Akakpo… - BMC genomics, 2017 - Springer
Background The 15 sibling species of the Paramecium aurelia cryptic species complex
emerged after a whole genome duplication that occurred tens of millions of years ago. Given …
emerged after a whole genome duplication that occurred tens of millions of years ago. Given …