Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Wound healing is a complex process that involves the coordinated actions of many different
tissues and cell lineages. It requires tight orchestration of cell migration, proliferation, matrix …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic
predisposition, epidermal barrier disruption, and dysregulation of the immune system are …

Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to
expel invading pathogens and noxious environmental stimuli. It is well established that …

Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to
local signals. ILCs are traditionally classified as ILC1, ILC2 or ILC3 on the basis of their …

Research over the last 7 years has led to the formal identification of innate lymphoid cells
(ILCs), increased the understanding of their tissue distribution and has established essential …

The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …

The innate immune system is composed of a diverse array of evolutionarily ancient
haematopoietic cell types, including dendritic cells, monocytes, macrophages and …

The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …