Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Diabetic retinopathy is the most frequently occurring complication of diabetes mellitus and
remains a leading cause of vision loss globally. Its aetiology and pathology have been …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

(CVD) in individuals with type 1 diabetes mellitus (T1DM), the pathophysiology underlying
the relationship between cardiovascular events, CVD risk factors, and T1DM is not well …

Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide and the
single strongest predictor of mortality in patients with diabetes. DKD is a prototypical disease …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …

Diabetic kidney disease (DKD) remains one of the leading causes of reduced lifespan in
diabetes. The quest for both prognostic and surrogate endpoint biomarkers for advanced …

The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …