Sex is a significant source of heterogeneity in schizophrenia, with more negative symptoms
in males and more affective symptoms and internalizing comorbidity in females. In this …

Context Clinicians, researchers, and global health advocates often include pubertal
development in outcomes. However, assessments of pubertal stage can be challenging …

The significant decline in academic engagement through the early stages of adolescence is
well known, however, the relative contribution of the key factors explaining these adolescent …

Context Vitamin D status is conventionally defined by measurement of unconjugated
circulating 25-hydroxyvitamin D (25OHD), but it remains uncertain whether this isolated …

Although an acceleration of male pubertal development has been observed, precisely which
endocrine-disrupting chemicals (EDCs) might contribute to the advancing onset of puberty in …

Urine is a biological matrix that contains hundreds of metabolic end products which
constitute the urinary metabolome. The development and advances on LC–MS/MS have …

In lifecourse studies that encompass the adolescent period, the assessment of pubertal
status is important, but can be challenging. We aimed to identify current methods for pubertal …

Context Although gonadotropin-releasing hormone stimulation test (GnRHST) is the gold
standard in diagnosing central precocious puberty (CPP), it is invasive, expensive, and time …

Introduction In large community-based studies of puberty, Tanner staging by a clinician is
often not possible. We compared self-rated Tanner staging and other subjective ratings of …

Biomarkers are incorporated ubiquitously into clini-cal practice as surrogate endpoints of
physiologic and pathologic processes that cannot be measured directly. For example, a lipid …