Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically
heterogeneous. Taking into account that also off‐target activities of drugs may lead to …

Isoniazid (INH) remains a mainstay for the treatment of tuberculosis despite the fact that it
can cause liver failure. Previous mechanistic hypotheses have classified this type of drug …

Importance The diagnostic properties of a graded provocation challenge (PC) among
children presenting with a rash in the course of amoxicillin treatment are currently unknown …

Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DIHS/DRESS) is a severe type of adverse drug eruption associated with …

Drug hypersensitivity reactions (DHR) are clinically and functionally heterogeneous.
Different subclassifications based on timing of symptom appearance or type of immune …

Most immune-mediated adverse drug reactions (IM-ADRs) involve the skin, and many have
additional systemic features. Severe cutaneous adverse drug reactions (SCARs) are an …

Drug hypersensitivity reactions (DHRs) are a diverse group of reactions mediated by the
immune system after exposure to a drug. The mechanisms underlying the development of a …

Individuals differ substantially in their response to pharmacological treatment. Personalized
medicine aspires to embrace these inter-individual differences and customize therapy by …

Background Pharmacogenetics is not a new subject area but its relevance to drug
prescribing has become clearer in recent years due to developments in gene cloning and …