Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Pseudomonas aeruginosa is an opportunistic pathogen able to infect any human tissue.
One of the reasons for its high adaptability and colonization of host tissues is its capacity of …

Background Pseudomonas aeruginosa is one of the most common pathogens that lead to
fatal human infection. This Gram-negative pathogen has evolved complex drug resistance …

In Pseudomonas aeruginosa, the ferric uptake regulator (Fur) protein controls both
metabolism and virulence in response to iron availability. Differently from other bacteria …

Ferritins are highly conserved supramolecular protein nanostructures composed of two
different subunit types, H (heavy) and L (light). The two subunits co-assemble into a 24 …

Bacterioferritin (Bfr) is a subfamily of ferritin protein family. Bfrs are composed of 24 identical
subunits and self-assemble into 4‐3-2-fold symmetric cage-like structure with the …

Iron plays a vital role in the maintenance of life, being central to various cellular processes,
from respiration to gene regulation. It is essential for iron to be stored in a nontoxic and …

Much evidence indicates that iron stored in ferritin is mobilized through protein degradation
in lysosomes, but concerns about this process have lingered, and the mechanistic details of …

Ferritins are iron storage proteins assembled from 24 subunits into a spherical and hollow
structure. The genomes of many bacteria harbor genes encoding two types of ferritin-like …

Although iron is essential for bacteria, the nutrient presents problems of toxicity and
solubility. Bacteria circumvent these problems with the aid of iron storage proteins where …