Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …

Advances in the study of exosomes derived from mesenchymal stem cells and cardiac cells for the treatment of myocardial infarction

Y Liu, M Wang, Y Yu, C Li, C Zhang - Cell Communication and Signaling, 2023 - Springer
Acute myocardial infarction has long been the leading cause of death in coronary heart
disease, which is characterized by irreversible cardiomyocyte death and restricted blood …

A systematic review and meta‐analysis of clinical trials assessing safety and efficacy of human extracellular vesicle‐based therapy

M Van Delen, J Derdelinckx, K Wouters… - Journal of …, 2024 - Wiley Online Library
Nowadays, it has become clear that extracellular vesicles (EVs) are not a cellular waste
disposal vesicle but are an essential part of an intercellular communication system. Besides …

Extracellular vesicles for therapeutic nucleic acid delivery: loading strategies and challenges

A Oshchepkova, M Zenkova, V Vlassov - International Journal of …, 2023 - mdpi.com
Extracellular vesicles (EVs) are membrane vesicles released into the extracellular milieu by
cells of various origins. They contain different biological cargoes, protecting them from …

Local delivery strategies for peptides and proteins into the CNS: Status Quo, challenges, and future perspectives

W Yue, J Shen - Pharmaceuticals, 2023 - mdpi.com
Over the past decades, peptides and proteins have been increasingly important in the
treatment of various human diseases and conditions owing to their specificity, potency, and …

Exosomes for angiogenesis induction in ischemic disorders

K Moeinabadi‐Bidgoli, M Rezaee… - Journal of cellular …, 2023 - Wiley Online Library
Ischaemic disorders are leading causes of morbidity and mortality worldwide. While the
current therapeutic approaches have improved life expectancy and quality of life, they are …

Fucoxanthin diminishes oxidative stress damage in human placenta-derived mesenchymal stem cells through the PI3K/Akt/Nrf-2 pathway

G Suwanmanee, C Tantrawatpan, P Kheolamai… - Scientific Reports, 2023 - nature.com
Placenta-derived mesenchymal stem cells (PL-MSCs) have therapeutic potential in various
clinical contexts due to their regenerative and immunomodulatory properties. However, with …

Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases

WH Bouche Djatche, H Zhu, W Ma, Y Li, Z Li… - Regenerative …, 2023 - Taylor & Francis
Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is
partially due to its secreted factors as opposed to the implantation of the cells into the treated …

Research hotspots and frotiers of stem cells in stroke: A bibliometric analysis from 2004 to 2022

Q Zhang, Y Zeng, S Zheng, L Chen, H Liu… - Frontiers in …, 2023 - frontiersin.org
Background: Stroke is one of the leading causes of mortality and permanent disability
worldwide. However, the current stroke treatment has a limited effect. Therefore, a new …

Neural stem cell-derived exosomes improve neurological function in rats with cerebral ischemia-reperfusion injury by regulating microglia-mediated inflammatory …

X Zhao, J Zhu, S Chen, R Liu, T Long - Journal of Inflammation …, 2023 - Taylor & Francis
Purpose To investigate the effect of neural stem cell-derived exosomes (NSC-Exos) on
neural function after rat cerebral ischemia-reperfusion injury by regulating microglia …