Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

The presence of symptom clusters, regional differences in disease expression and
similarities with, for example, Crohn's disease suggest multiple pathological pathways are …

Transcriptome-wide association analysis is a powerful approach to studying the genetic
architecture of complex traits. A key component of this approach is to build a model to impute …

Behcet's disease (BD) is a chronic systemic inflammatory vasculitis of unknown etiology
characterized by recurrent episodes of oral aphthous ulcers, genital ulcers, skin lesions …

JAKs and STATs in Immunity, Immunodeficiency, and Cancer | New England Journal of Medicine
Skip to main content The New England Journal of Medicine homepage Advanced Search …

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …

Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous
or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an …