Reactive oxygen species (ROS), which were originally characterized in terms of their
harmful effects on cells and invading microorganisms, are increasingly implicated in various …

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

Broadly, tissue regeneration is achieved in two ways: by proliferation of common
differentiated cells and/or by deployment of specialized stem/progenitor cells. Which of these …

Lineage tracing is the identification of all progeny of a single cell. Although its origins date
back to developmental biology of invertebrates in the 19 th century, lineage tracing is now …

Glial cells were long considered end products of neural differentiation, specialized
supportive cells with an origin very different from that of neurons. New studies have shown …

Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can
be isolated from many adult tissues. They can differentiate into cells of the mesodermal …

Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many
tissues, activation of Wnt signalling has also been associated with cancer. This has raised …

The identity of cells that establish the hematopoietic microenvironment (HME) in human
bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long …

Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair
tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling …