Oligodendrocytes in development, myelin generation and beyond
S Kuhn, L Gritti, D Crooks, Y Dombrowski - Cells, 2019 - mdpi.com
Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …
Overcoming therapeutic resistance in glioblastoma: the way forward
S Osuka, EG Van Meir - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …
Generation of functional human 3D cortico-motor assembloids
Neurons in the cerebral cortex connect through descending pathways to hindbrain and
spinal cord to activate muscle and generate movement. Although components of this …
spinal cord to activate muscle and generate movement. Although components of this …
[HTML][HTML] Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution
Genetic perturbations of cortical development can lead to neurodevelopmental disease,
including autism spectrum disorder (ASD). To identify genomic regions crucial to …
including autism spectrum disorder (ASD). To identify genomic regions crucial to …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
The major cell classes of the brain differ in their developmental processes, metabolism,
signaling, and function. To better understand the functions and interactions of the cell types …
signaling, and function. To better understand the functions and interactions of the cell types …
A novel m6A reader Prrc2a controls oligodendroglial specification and myelination
Abstract While N 6-methyladenosine (m6A), the most abundant internal modification in
eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological …
eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological …
A latent lineage potential in resident neural stem cells enables spinal cord repair
INTRODUCTION The capacity of a tissue to regenerate itself rests on the potential of its
resident cells to replace cells lost to injury. Some tissues, such as skin or intestine, do this …
resident cells to replace cells lost to injury. Some tissues, such as skin or intestine, do this …
Oligodendrocyte development and plasticity
DE Bergles, WD Richardson - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain
and spinal cord and migrate throughout the developing central nervous system (CNS) …
and spinal cord and migrate throughout the developing central nervous system (CNS) …
Motor neurons and the generation of spinal motor neuron diversity
N Stifani - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …
controlling a variety of downstream targets. This function infers the existence of MN subtypes …