Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Nrf2 and its endogenous inhibitor, Keap1, function as a ubiquitous, evolutionarily conserved
intracellular defense mechanism to counteract oxidative stress. Sequestered by cytoplasmic …

Electrophiles and reactive oxygen species (ROS) play a major role in modulating cellular
defense mechanisms as well as physiological functions, and intracellular signaling …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Alzheimer's disease (AD) is the number one neurovegetative disease, but its treatment
options are relatively few and ineffective. In efforts to discover new strategies for AD therapy …

Abstract According to the United States Centers for Disease Control and Prevention (CDC),
as of July 11, 2016, the reported average incidence of children diagnosed with an autism …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …