Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C
has advanced the prospect of developing antifibrotic therapies for patients with chronic liver …

Ghrelin, a gastric-derived acylated peptide, regulates energy homeostasis by transmitting
information about peripheral nutritional status to the brain, and is essential for protecting …

There have been considerable recent advances towards a better understanding of the
complex cellular and molecular network underlying liver fibrogenesis. Recent data indicate …

Cirrhosis is a chronic condition that can lead to liver failure. Currently, the viable option for
decreasing mortality is liver transplantation. However, transplant surgery is highly invasive …

Liver cirrhosis is frequently accompanied by disease-related malnutrition (DRM) and
sarcopenia, defined as loss of skeletal muscle mass and function. DRM and sarcopenia …

Obesity, diabetes, insulin resistance, sedentary lifestyle, and Western diet are the key factors
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …

Fibrosis accumulation is a dynamic process resulting from a wound-healing response to
acute or chronic liver injury of all causes. The cascade starts with hepatocyte necrosis and …

The innate immune system represents the first-line response to invading microbes, tissue
damage, or aberrant cell growth. Many of the proteins and cells involved in innate immunity …

Liver fibrosis is a dynamic pathological condition which can be slowed down in its initial
phases. Without proper clinical management of fibrosis, progressive liver damage may lead …

Nonalcoholic fatty liver disease (NAFLD) has gained importance in recent decades due to
drastic changes in diet, especially in Western countries. NAFLD occurs as a spectrum from …