Drug delivery systems (DDS) are defined as methods by which drugs are delivered to
desired tissues, organs, cells and subcellular organs for drug release and absorption …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due
to the simultaneous overproduction of reactive oxygen species and glutathione. Rational …

Disulfide bonds have been widely used to develop reduction-responsive drug-delivery
systems (DDS) for cancer therapy. We propose that disulfide bonds might be also used as …

This article provides a broad spectrum about the nanoprodrug fabrication advances co‐
driven by prodrug and nanotechnology development to potentiate cancer treatment. The …

Clinical applications of many anti-cancer drugs are restricted due to their hydrophobic
nature, requiring use of harmful organic solvents for administration, and poor selectivity and …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths.
Unfortunately, there is still no completely effective treatment. Ferroptosis could affect the …

Despite that great progression has been made in nanoparticulate drug delivery systems
(nano-DDS), multiple drug delivery dilemmas still impair the delivery efficiency of …

Background Cancer is one of the deadliest threats to human health. Abnormal
physiochemical conditions and dysregulated biosynthetic intermediates in the tumor …