The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and
functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation …

The glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the
treatment of inflammatory disorders and several cancers. Despite the effectiveness of GR …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Atopic dermatitis (AD), a prevalent chronic inflammatory disease with multifactorial etiology,
features epidermal barrier defects and immune overactivation. Synthetic glucocorticoids …

Glucocorticoids (GCs) exert potent antiproliferative and anti-inflammatory properties,
explaining their therapeutic efficacy for skin diseases. GCs act by binding to the GC receptor …

Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic
homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their …

Glucocorticoids are essential hormones produced by the adrenal cortex with prominent
circadian rhythmicity and in times of stress. Glucocorticoids maintain liver homeostasis …

The prevailing model of steroid hormone nuclear receptor function assumes ligand-induced
homodimer formation followed by binding to DNA hormone response elements (HREs). This …

Glucocorticoids (GCs) are hormones involved in circadian adaptation and stress response,
and it is also noteworthy that these steroidal molecules present potent anti-inflammatory …

The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members
of the steroid receptor subfamily of nuclear receptors. Their main function is to act as ligand …