Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …

Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at
the nuclear lamina (NL). A major question is how LAD–NL interactions are mediated and …

Cells responding to DNA damage implement complex adaptive programs that often
culminate in one of two distinct outcomes: apoptosis or senescence. To systematically …

Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age
and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and …

N‐6‐Methyladenosine (m6A) modification is involved in multiple biological processes
including aging. However, the regulation of m6A methyltransferase‐like 14 (METTL14) in …

Mechanical forces may be generated within a cell due to tissue stiffness, cytoskeletal
reorganization, and the changes (even subtle) in the cell's physical surroundings. These …

Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the
genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is …

Infrapatellar fat pad (IPFP) is closely associated with the development and progression of
knee osteoarthritis (OA), but the underlying mechanism remains unclear. Here, it is find that …

Mammalian somatic cells undergo terminal proliferation arrest after a limited number of cell
divisions, a phenomenon termed cellular senescence. However, cells acquire the ability to …

Senescence is defined as a gradual weakening of functional features of a living organism.
Cellular senescence is a process that is principally aimed to remove undesirable cells by …