Identification of RNA structures and their roles in RNA functions

X Cao, Y Zhang, Y Ding, Y Wan - Nature Reviews Molecular Cell …, 2024 - nature.com
The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Translational regulation by uORFs and start codon selection stringency

TE Dever, IP Ivanov, AG Hinnebusch - Genes & development, 2023 - genesdev.cshlp.org
In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic
mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing …

[HTML][HTML] Pervasive downstream RNA hairpins dynamically dictate start-codon selection

Y Xiang, W Huang, L Tan, T Chen, Y He, PS Irving… - Nature, 2023 - nature.com
Translational reprogramming allows organisms to adapt to changing conditions. Upstream
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …

Folding the mitochondrial UPR into the integrated stress response

NS Anderson, CM Haynes - Trends in cell biology, 2020 - cell.com
Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to
overcome environmental insults and respond to physiological cues. The mitochondrial …

A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

D Kim, S Kim, J Park, HR Chang, J Chang… - Nature …, 2021 - nature.com
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which infected> 200 million people resulting in> 4 million deaths. However, temporal …

Noncoding translation mitigation

JS Kesner, Z Chen, P Shi, AO Aparicio, MR Murphy… - Nature, 2023 - nature.com
Translation is pervasive outside of canonical coding regions, occurring in long noncoding
RNAs, canonical untranslated regions and introns,,–, especially in ageing …

Natural uORF variation in plants

J Wang, J Liu, Z Guo - Trends in Plant Science, 2024 - cell.com
Taking advantage of natural variation promotes our understanding of phenotypic diversity
and trait evolution, ultimately accelerating plant breeding, in which the identification of …

A natural uORF variant confers phosphorus acquisition diversity in soybean

Z Guo, H Cao, J Zhao, S Bai, W Peng, J Li… - Nature …, 2022 - nature.com
Phosphorus (P) is an essential element for all organisms. Because P fertilizers are a non-
renewable resource and high fixation in soils, sustainable agriculture requires researchers …

Protein synthesis control in cancer: selectivity and therapeutic targeting

JR Kovalski, D Kuzuoglu‐Ozturk, D Ruggero - The EMBO Journal, 2022 - embopress.org
Translational control of mRNAs is a point of convergence for many oncogenic signals
through which cancer cells tune protein expression in tumorigenesis. Cancer cells rely on …

Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

Z Na, X Dai, SJ Zheng, CJ Bryant, KH Loh, H Su, Y Luo… - Molecular cell, 2022 - cell.com
Proteogenomic identification of translated small open reading frames has revealed
thousands of previously unannotated, largely uncharacterized microproteins, or …