Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic
materials to lysosomes via autophagosomes. Recent advances have enabled identification …

Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells
recycle or degrades internal constituents through membrane-trafficking pathway. Thus …

The mTORC1 kinase is a master growth regulator that senses many environmental cues,
including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly …

The lysosome degrades and recycles macromolecules, signals to the master growth
regulator mTORC1 [mechanistic target of rapamycin (mTOR) complex 1], and is associated …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …

Background: Depression is a mental disorder that poses a serious threat to human health.
Adult hippocampal neurogenesis (AHN) is closely associated with the efficacy of …