The development and functions of multiciliated epithelia

N Spassky, A Meunier - Nature reviews Molecular cell biology, 2017 - nature.com
Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

The genetic architecture of morphological abnormalities of the sperm tail

A Touré, G Martinez, ZE Kherraf, C Cazin, J Beurois… - Human Genetics, 2021 - Springer
Spermatozoa contain highly specialized structural features reflecting unique functions
required for fertilization. Among them, the flagellum is a sperm-specific organelle required to …

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

A Zeisel, AB Muñoz-Manchado, S Codeluppi… - Science, 2015 - science.org
The mammalian cerebral cortex supports cognitive functions such as sensorimotor
integration, memory, and social behaviors. Normal brain function relies on a diverse set of …

A latent lineage potential in resident neural stem cells enables spinal cord repair

E Llorens-Bobadilla, JM Chell, P Le Merre, Y Wu… - Science, 2020 - science.org
INTRODUCTION The capacity of a tissue to regenerate itself rests on the potential of its
resident cells to replace cells lost to injury. Some tissues, such as skin or intestine, do this …

[HTML][HTML] Single-cell RNA-seq reveals cellular hierarchies and impaired developmental trajectories in pediatric ependymoma

J Gojo, B Englinger, L Jiang, JM Hübner, MKL Shaw… - Cancer cell, 2020 - cell.com
Ependymoma is a heterogeneous entity of central nervous system tumors with well-
established molecular groups. Here, we apply single-cell RNA sequencing to analyze …

Normal Table of Xenopus development: a new graphical resource

N Zahn, C James-Zorn, VG Ponferrada… - …, 2022 - journals.biologists.com
Normal tables of development are essential for studies of embryogenesis, serving as an
important resource for model organisms, including the frog Xenopus laevis. Xenopus has …

Multiciliated cells

ER Brooks, JB Wallingford - Current biology, 2014 - cell.com
Cilia are microtubule-based projections that serve a wide variety of essential functions in
animal cells. Defects in cilia structure or function have recently been found to underlie …

Single-cell analysis of shared signatures and transcriptional diversity during zebrafish development

A Sur, Y Wang, P Capar, G Margolin, MK Prochaska… - Developmental Cell, 2023 - cell.com
During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo

G Ventura, A Amiri, R Thiagarajan, M Tolonen… - Nature …, 2022 - nature.com
During embryonic development, regeneration, and homeostasis, cells have to migrate and
physically integrate into the target tissues where they ultimately execute their function. While …

TAp73 is a central transcriptional regulator of airway multiciliogenesis

A Nemajerova, D Kramer, SS Siller, C Herr… - Genes & …, 2016 - genesdev.cshlp.org
Motile multiciliated cells (MCCs) have critical roles in respiratory health and disease and are
essential for cleaning inhaled pollutants and pathogens from airways. Despite their …