[HTML][HTML] A preclinical overview of metformin for the treatment of type 2 diabetes
T Zhou, X Xu, M Du, T Zhao, J Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Abstract Type 2 diabetes (T2D) is the most common type of diabetes mellitus and is mainly
characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output …
characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output …
Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels
T Zhou, Z Wang, M Guo, K Zhang, L Geng, A Mao… - Food & function, 2020 - pubs.rsc.org
Puerarin (Pue) is an isoflavone derived from the root of Pueraria lobata, which has been
widely used as food and a herb for treating cardiovascular and cerebrovascular diseases …
widely used as food and a herb for treating cardiovascular and cerebrovascular diseases …
Mebhydrolin ameliorates glucose homeostasis in type 2 diabetic mice by functioning as a selective FXR antagonist
Introduction Type 2 diabetes mellitus (T2DM) is a chronic disease with hallmarks of
hyperglycemia and hyperlipidemia. Long-term hyperglycemia damages the functions of …
hyperglycemia and hyperlipidemia. Long-term hyperglycemia damages the functions of …
Discovery and structure-activity relationships study of thieno [2, 3-b] pyridine analogues as hepatic gluconeogenesis inhibitors
Type 2 diabetes mellitus (T2DM) is a chronic, complex and multifactorial metabolic disorder,
and targeting gluconeogenesis inhibition is a promising strategy for anti-diabetic drug …
and targeting gluconeogenesis inhibition is a promising strategy for anti-diabetic drug …
Tandem synthesis and antibacterial screening of new thieno[2,3-b]pyridine-fused pyrimidin-4(3H)-ones linked to thiazole or oxazole units
New two series of thieno [2, 3-b] pyridine-fused pyrimidinones 1 and 2 linked to thiazole or
oxazole units were prepared utilizing a three-component tandem protocol. Therefore, a …
oxazole units were prepared utilizing a three-component tandem protocol. Therefore, a …
[HTML][HTML] FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway
X Xu, Y Chen, D Zhu, T Zhao, R Xu, J Wang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose
metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for …
metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for …
Synthesis and Properties of New Fluorine-Containing Thieno[2,3-b]pyridine Derivatives
DS Buryi, VV Dotsenko, NA Aksenov… - Russian Journal of …, 2019 - Springer
Abstract Cyanothioacetamide reacted with 1, 1, 5, 5-tetrafluoroacetylacetone to give 4, 6-bis
(difluoromethyl)-2-thioxo-1, 2-dihydropyridine-3-carbonitrile, and alkylation of the latter with …
(difluoromethyl)-2-thioxo-1, 2-dihydropyridine-3-carbonitrile, and alkylation of the latter with …
TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice
Activating transcription factor 6α (ATF6α) as a transducer in unfolded protein response
(UPR), plays an important role in liver glucose metabolism and insulin resistance. Thus …
(UPR), plays an important role in liver glucose metabolism and insulin resistance. Thus …
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
Gluconeogenesis is a major source of hyperglycemia in patients with type 2 diabetes
mellitus (T2DM), thus targeting gluconeogenesis to suppress glucose production is a …
mellitus (T2DM), thus targeting gluconeogenesis to suppress glucose production is a …
Синтез и свойства новых фторсодержащих производных тиено[2,3-b]пиридина
ДС Бурый, ВВ Доценко, НА Аксенов… - Журнал общей …, 2019 - elibrary.ru
Цианотиоацетамид реагирует с 1, 1, 5, 5-тетрафторацетилацетоном с образованием
4, 6-бис (дифторметил)-2-тиоксо-1, 2-дигидропиридин-3-карбонитрила, алкилирование …
4, 6-бис (дифторметил)-2-тиоксо-1, 2-дигидропиридин-3-карбонитрила, алкилирование …