Abstract Type 2 diabetes (T2D) is the most common type of diabetes mellitus and is mainly
characterized by insulin resistance, β-cell dysfunction, and elevated hepatic glucose output …

Puerarin (Pue) is an isoflavone derived from the root of Pueraria lobata, which has been
widely used as food and a herb for treating cardiovascular and cerebrovascular diseases …

Introduction Type 2 diabetes mellitus (T2DM) is a chronic disease with hallmarks of
hyperglycemia and hyperlipidemia. Long-term hyperglycemia damages the functions of …

Type 2 diabetes mellitus (T2DM) is a chronic, complex and multifactorial metabolic disorder,
and targeting gluconeogenesis inhibition is a promising strategy for anti-diabetic drug …

New two series of thieno [2, 3-b] pyridine-fused pyrimidinones 1 and 2 linked to thiazole or
oxazole units were prepared utilizing a three-component tandem protocol. Therefore, a …

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose
metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for …

Abstract Cyanothioacetamide reacted with 1, 1, 5, 5-tetrafluoroacetylacetone to give 4, 6-bis
(difluoromethyl)-2-thioxo-1, 2-dihydropyridine-3-carbonitrile, and alkylation of the latter with …

Activating transcription factor 6α (ATF6α) as a transducer in unfolded protein response
(UPR), plays an important role in liver glucose metabolism and insulin resistance. Thus …

Gluconeogenesis is a major source of hyperglycemia in patients with type 2 diabetes
mellitus (T2DM), thus targeting gluconeogenesis to suppress glucose production is a …

Цианотиоацетамид реагирует с 1, 1, 5, 5-тетрафторацетилацетоном с образованием
4, 6-бис (дифторметил)-2-тиоксо-1, 2-дигидропиридин-3-карбонитрила, алкилирование …