BRCA mutations in ovarian and prostate cancer: bench to bedside
Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …
Harnessing DNA double-strand break repair for cancer treatment
A Trenner, AA Sartori - Frontiers in oncology, 2019 - frontiersin.org
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher …
POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis
M Llorens-Agost, M Ensminger, HP Le, A Gawai… - Nature cell …, 2021 - nature.com
BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …
Replication fork reversal triggers fork degradation in BRCA2-defective cells
S Mijic, R Zellweger, N Chappidi, M Berti… - Nature …, 2017 - nature.com
Besides its role in homologous recombination, the tumor suppressor BRCA2 protects stalled
replication forks from nucleolytic degradation. Defective fork stability contributes to …
replication forks from nucleolytic degradation. Defective fork stability contributes to …
Regulation of single-strand annealing and its role in genome maintenance
R Bhargava, DO Onyango, JM Stark - Trends in Genetics, 2016 - cell.com
Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …
Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells
Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …
tend to actively proliferate more than normal cells. They have well-known side-effects …
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
PS Patel, A Algouneh, R Hakem - Oncogene, 2021 - nature.com
The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …
disruption of two genes, which, individually, do not cause lethality, has become an attractive …
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy
To maintain stable genomes and to avoid cancer and aging, cells need to repair a multitude
of deleterious DNA lesions, which arise constantly in every cell. Processes that support …
of deleterious DNA lesions, which arise constantly in every cell. Processes that support …
Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting
GE Ronson, K Starowicz, EJ Anthony… - Nature …, 2023 - nature.com
A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however …
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however …
RAD52: paradigm of synthetic lethality and new developments
MJ Rossi, SF DiDomenico, M Patel, AV Mazin - Frontiers in Genetics, 2021 - frontiersin.org
DNA double-strand breaks and inter-strand cross-links are the most harmful types of DNA
damage that cause genomic instability that lead to cancer development. The highest fidelity …
damage that cause genomic instability that lead to cancer development. The highest fidelity …