Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Organoids form through self-organization processes in which initially homogeneous
populations of stem cells spontaneously break symmetry and undergo in-vivo-like pattern …

Embryos allocate cells to the three germ layers in a spatially ordered sequence. Human
embryonic stem cells (hESCs) can generate the three germ layers in culture; however …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell …

Mesenchymal stem cells (MSCs) are multipotent stem cells. Although they were originally
identified in bone marrow and described as 'marrow stromal cells', they have since been …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Cell–material interactions constitute a key fundamental topic in biomaterials study. Various
cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials …

Artificial stimuli-responsive surfaces that can mimic the dynamic function of living systems
have attracted much attention. However, there exist few artificial systems capable of …

Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …